Drugs under trial for Corona virus (SARS-COV-2) or COVID-19

Drugs under trial for SARS-COV-2 or COVID-19

As of 22nd april 2020, 650 trials are ongoing to find cure against corona virus. I have gone through all those trials and selected around 50 most promising drugs.

The target for the drugs in trial can be divided in to six categories i.e.

1. Drugs acting on virus

a. Camostat mesilate
b. Bromhexine
c. Hydroxychloroquine
d. Mefloquine
e. Remidesivir
f. Favipiravir
g. Galidesivir
h. LPV/r
i. Nitazoxanide
j. Ivermectin
k. Arbidol (Umifenovir)
l. Meplazumab
m. Azithromycin

2. Drugs inhibiting immune system

a. IL-6 blockers (Tocilizumab, Sarilumab, Siltuximab, Clazakizumab)
b. IL-1 blocker (Anakinra)
c. JAK blockers (Tofacitinib, Baricitinib, Ruxolitinib)
d. GMCSFR blocker (Mavrilimumab)
e. Thalidomide
f. Fingolimod
g. Adenosine A3 receptor agonist (Piclidenoson)
h. PD-1 Ligand blocker (Nivolumab)
i. Pyridostigmine
j. Colchicine
k. Fluvoxamine
l. Complement 5 blocker (Eculizumab)
m. VIP analog (Aviptadil)
n. Sirolimus

3. Drugs stimulating immune system

a. Sargamostim
b. Levamisole

4. Drugs acting on ARDS

a. Sildenafil
b. Bevacizumab
c. Defibrotide
d. Spironolactone

5. Drugs acting on pulmonary fibrosis

a. Tetrandine
b. Nintedanib

6. Miscellaneous drugs

a. Deferoxamine
b. Naproxen
c. Ciclesonide
d. Tranexamic acid
e. Vitamin C and D
f. Zinc
g. Liothyronine
h. BCG vaccine

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